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CyFlow™ CD1a Purified

CyFlow™ CD1a Purified
Application: Flow cytometry, Immunoprecipitation
Antigen: CD1a
Alternative Name: CD1, HTA1, R4
Clone: SK9
Clonality: monoclonal
Target Species: Human
Regulatory Status: RUO
Isotype: IgG2b
Source Species: Mouse
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Order number: BE397755

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

HLDA Workshop HLDA II Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg... more
CyFlow™ CD1a Purified
Concentration Unitmg/mL
Quantity0.1 mg
Volume0.1 mL
ImmunogenHuman thymocytes
Background InformationCD1a, together with CD1b and CD1c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Wood GS, Burns BF, Dorfman RF, Warnke RA: The immunohistology of non‑T cells in the acquired immunodeficiency syndrome. Am·J·Pathol. 1985·Sep; 120(3):371‑9. <·PMID:·3898858·> | Zimmer MI, Larregina AT, Castillo CM, Capuano S 3rd, Falo LD Jr, Murphey-Corb M, Reinhart TA, Barratt-Boyes SM: Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 2002·Apr·15; 99(8):2859‑68. <·PMID:·11929776·> | Tenca C, Merlo A, Zarcone D, Saverino D, Bruno S, De Santanna A, Ramarli D, Fabbi M, Pesce C, Deaglio S, Ciccone E, Malavasi F, Grossi CE: Death of T cell precursors in the human thymus: a role for CD38. Int·Immunol. 2003·Sep; 15(9):1105‑16. <·PMID:·12917263·> | Brown KN, Trichel A, Barratt-Boyes SM: Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J·Immunol. 2007·Jun·1; 178(11):6958‑67. <·PMID:·17513745·> | Awasthi S, Wolf R, White G: Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol·Cell·Biol. 2009·Jul; 87(5):419‑27. <·PMID:·19223853·> | Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM: Blocking TLR7‑ and TLR9‑mediated IFN‑α: production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS·Pathog. 2013; 9(7):e1003530. <·PMID:·23935491·>