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CyFlow™ CD79a Purified

CyFlow™ CD79a Purified
Antigen: CD79a
Alternative Name: IgA, MB-1, MB1
Clone: HM57
Application: Flow cytometry, Immunohistochemistry
Format/Fluorochrome: Purified
Target Species: Chicken, Cow, Guinea pig, Horse, Human, Mouse, Opossum, Pig, Rabbit, Rat
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: AA059748

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

HLDA Workshop HLDA V—WS Code BC cB018 HLDA VI—WS Code BP 193 HLDA VI—WS Code BP 89 HLDA VI—WS... more
CyFlow™ CD79a Purified
HLDA WorkshopHLDA V—WS Code BC cB018 HLDA VI—WS Code BP 193 HLDA VI—WS Code BP 89 HLDA VI—WS Code B B103 HLDA VI—WS Code B CD79.4
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1
ImmunogenSynthetic peptide corresponding to amino acids 202-216 of human CD79a
Background InformationCD79a (Ig α, MB1) forms disulfide-linked heterodimer with CD79b (Ig β, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

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