Welcome to
Sysmex Flow Cytometry Austria!

For ordering please make sure you are in your local shop.
If you are from Austria then please continue.
Otherwise please go to your country.

Go to my country Continue

Article successfully added.

CyFlow™ CD42a Purified

CyFlow™ CD42a Purified
Antigen: CD42a
Alternative Name: GPIX
Clone: GR-P
Application: Flow cytometry
Format/Fluorochrome: Purified
Target Species: Dog, Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: AK114812

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Attention:

Order 2, get the lower priced for free

*1
*1 Offer valid until 31/10/2017
HLDA Workshop HLDA IV—WS Code P 35 Concentration Unit mg/mL Concentration 1... more
CyFlow™ CD42a Purified
HLDA WorkshopHLDA IV—WS Code P 35
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1
ImmunogenHuman Acute Lymphocytic Leukemia (ALL) T cells
Background InformationCD42a (GPIX; Glycoprotein 9) composes together with GPIb α, GPIb β and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Knapp W, Dorken B, Gilks W, Rieber EP, Schmidt RE, Stein H, von dem Borne AEGK (Eds): Leucocyte Typing IV. Oxford·University·Press,·Oxford. 1989; 1‑1820. <·NLM·ID:·8914679·> | Brown SB, Clarke MC, Magowan L, Sanderson H, Savill J: Constitutive death of platelets leading to scavenger receptor‑mediated phagocytosis: A caspase‑independent cell clearance program. J·Biol·Chem. 2000·Feb·25; 275(8):5987‑96. <·PMID:·10681593·> | Harding SA, Din JN, Sarma J, Josephs DH, Fox KA, Newby DE: Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin. Heart. 2006·Nov; 92(11):1635‑8. <·PMID:·16709700·> | Vettore S, Scandellari R, Moro S, Lombardi AM, Scapin M, Randi ML, Fabris F: Novel point mutation in a leucine‑rich repeat of the GPIb alpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard‑Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica. 2008·Nov; 93(11):1743‑7. <·PMID:·18815197·> | Din JN, Aftab SM, Jubb AW, Carnegy FH, Lyall K, Sarma J, Newby DE, Flapan AD: Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans. Eur·J·Clin·Nutr. 2011·Feb; 65(2):234‑9. <·PMID:·21048773·>