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CyFlow™ CD62L Low Endotoxin

CyFlow™ CD62L Low Endotoxin
Antigen: CD62L
Alternative Name: L-Selectin
Clone: MEL-14
Application: Flow cytometry, Functional assays, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation
Format/Fluorochrome: Low Endotoxin
Target Species: Mouse
Field of Interest: Immunophenotyping, MHC
Species of Origin: Rat
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG2a
Order number: CB293005

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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*1
*1 Offer valid until 31/10/2017
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 Immunogen... more
CyFlow™ CD62L Low Endotoxin
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1
ImmunogenC3H/eb mouse B cell lymphoma 38C-13
Background InformationCD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Gallatin WM, Weissman IL, Butcher EC: A cell‑surface molecule involved in organ‑specific homing of lymphocytes. Nature. 1983·Jul·7; 304:30‑34. <·PMID:·6866086·> | Brawand P, Cerottini JC, MacDonald HR: Hierarchal utilization of different T‑cell receptor Vbeta gene segments in the CD8(+)‑T‑cell response to an immunodominant Moloney leukemia virus‑encoded epitope in vivo. J·Virol. 1999·Nov; 73(11):9161‑9. <·PMID:·10516023·> | ten Bruggencate SJ, Hillyer LM, Woodward BD: The proportion of CD45RA(+)CD62L(+) (quiescent‑phenotype) T cells within the CD8(+) subset increases in advanced weight loss in the protein‑ or energy‑deficient weanling mouse. J·Nutr. 2001·Dec; 131(12):3266‑9. <·PMID:·11739878·> | Mannering SI, Cheers C: Interleukin‑2 and loss of immunity in experimental Mycobacterium avium infection. Infect·Immun. 2002·Jan; 70(1):27‑35. <·PMID:·11748160·> | Friedline RH, Wong CP, Steeber DA, Tedder TF, Tisch R: L‑selectin is not required for T cell‑mediated autoimmune diabetes. J·Immunol. 2002·Mar·15; 168(6):2659‑66. <·PMID:·11884430·> | Fisson S, Darrasse-Jèze G, Litvinova E, Septier F, Klatzmann D, Liblau R, Salomon BL: Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J·Exp·Med. 2003·Sep·1; 198(5):737‑46. <·PMID:·12939344·> | Chen BJ, Cui X, Sempowski GD, Liu C, Chao NJ: Transfer of allogeneic CD62L‑ memory T cells without graft‑versus‑host disease. Blood. 2004·Feb·15; 103(4):1534‑41. <·PMID:·14551132·> | Chin CS, Miller CH, Graham L, Parviz M, Zacur S, Patel B, Duong A, Bear HD: Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L‑selectinlow tumor‑sensitized lymphocytes. Int·Immunol. 2004·Sep; 16(9):1283‑94. <·PMID:·15262898·> | Pop SM, Wong CP, He Q, Wang Y, Wallet MA, Goudy KS, Tisch R: The type and frequency of immunoregulatory CD4+ T‑cells govern the efficacy of antigen‑specific immunotherapy in nonobese diabetic mice. Diabetes. 2007·May; 56(5):1395‑402. <·PMID:·17317763·> | Richards H, Longhi MP, Wright K, Gallimore A, Ager A: CD62L (L‑selectin) down‑regulation does not affect memory T cell distribution but failure to shed compromises anti‑viral immunity. J·Immunol. 2008·Jan·1; 180(1):198‑206. <·PMID:·18097020·> | Xu H, Manivannan A, Crane I, Dawson R, Liversidge J: Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation. Blood. 2008·Aug·15; 112(4):1166‑74. <·PMID:·18391078·>