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CyFlow™ CD42b Purified

CyFlow™ CD42b Purified
Antigen: CD42b
Alternative Name: GPIba
Clone: AK2
Application: Enzyme-linked immunosorbent assay, Flow cytometry, Immunocytochemistry, Immunoprecipitation, Western blot
Format/Fluorochrome: Purified
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: AB107492

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen Human platelets... more
CyFlow™ CD42b Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenHuman platelets
SpecifityThe mouse monoclonal antibody AK2 recognizes CD42b antigen, a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
Background InformationCD42b (GPIb α) composes together with GPIb β, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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