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CyFlow™ CD8a FITC

CyFlow™ CD8a FITC
Antigen: CD8a
Alternative Name: Leu2, T8
Clone: 53-6.7
Application: Flow cytometry
Format/Fluorochrome: FITC
Laser: Blue
Target Species: Mouse
Field of Interest: Immunophenotyping, MHC
Species of Origin: Rat
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 518 nm
Excitation Maximum: 490 to 495 nm
Isotype: IgG2a
Order number: BR814264

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 0.5 mg/ml Quantity 0.1 mg Volume 0.2 ml Immunogen Mouse spleen... more
CyFlow™ CD8a FITC
Concentration0.5 mg/ml
Quantity0.1 mg
Volume0.2 ml
ImmunogenMouse spleen cells
SpecifityThe rat monoclonal antibody 53-6.7 recognizes mouse CD8a antigen, a 32-34 kDa α chain of the CD8 antigen.
Background InformationThe CD8a (CD8 α) subunit of CD8 T cell coreceptor is expressed in CD8 α/β heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 α/α homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 α/β but not α/α dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
UsageThe reagent is designed for Flow Cytometry analysis. Suggested working usage is 2·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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